许琪，2004年毕业于中国协和医科大学，获博士学位。现任天美麻花星空视频基础医学研究所/北京协和医学院基础学院副所院长，天美麻花星空视频神经科学中心常务副主任（主持工作），天美麻花星空视频长聘教授，国家级重大人才项目入选者，国家杰出青年基金获得者。长期从事抑郁症、精神分裂症、难治性癫痫、痴呆等重性脑疾病的发病机制与诊疗靶标研究。在Nature、Neuron、American Journal of Psychiatry、Journal of Experimental Medicine等期刊发表通讯作者论文80余篇，成果被Nature、Nature Reviews Drug Discovery等广泛报道

研究方向为重性脑疾病的发病机制和诊断治疗靶标研究，主要研究内容包括：重性脑疾病的遗传学与表观遗传学研究；重性脑疾病的致病机制研究；重性脑疾病的治疗靶点和新药研发；重性脑疾病的干细胞与再生医学研究。

天美麻花星空视频

1. Jianbo Xiu#, Jiayu Li#, Zeyue Liu#, Hui Wei, Caiyun Zhu, Rongrong Han, Zijing Liu, Wanwan Zhu, Yan Shen, Qi Xu*. Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice. Proc Natl Acad Sci USA. 2022. 119(30):e2201967119. (IF=12.77)

2. Enhui He#, You Zhou#, Jinping Luo, Shihong Xu, Kui Zhang, Yilin Song, Mixia Wang, Shengwei Xu, Yuchuan Dai, Gucheng Yang, Jingyu Xie, Zhaojie Xu, Wanwan Zhu, Yu Deng, Qi Xu*, Xinxia Cai*. Sensitive detection of electrophysiology and dopamine vesicular exocytosis of hESC-derived dopaminergic neurons using multifunctional microelectrode array. Biosens Bioelectron. 2022. 209:114263. (IF=12.54)

3. Shu Liu#, Jianbo Xiu#, Caiyun Zhu#, Kexin Meng#, Chen Li, Rongrong Han, Tingfu Du, Lanlan Li, Lingdan Xu, Renjie Liu, Wanwan Zhu, Yan Shen, Qi Xu*. Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice. Nat Commun. 2021. 26;12(1):6937. (IF=14.91)

4. Qiu-Wen Wang#, Si-Yao Lu#, Yao-Nan Liu#, Yun Chen, Hui Wei, Wei Shen, Yan-Fen Chen, Chong-Lei Fu, Ying-Han Wang, Anbang Dai, Xuan Huang, Fred H Gage, Qi Xu*, Jun Yao*. Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. Proc Natl Acad Sci USA. 2020. 117(49):31438-31447. (IF=11.20)

5. Lige Leng#, Kai Zhuang#, Zeyue Liu#, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu*, Jie Zhang*. Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron. 2018. 100(3):551-563. (IF=14.43)

6. Longze Sha#, Xueqin Wang#, Jing Li, Xinze Shi, Liwen Wu, Yan Shen, Qi Xu*. Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy. J Exp Med. 2017. 214(2):547-563. (IF=11.99)

7. Na Cai#, Tim B. Bigdeli#, Warren Kretzschmar#, Yihan Li #, Qi Xu*, Jun Wang*, Kenneth S. Kendler* & Jonathan Flint*. Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature. 2015. 523(7562):588-91. (IF=37.54, F1000)

8. Hui Wei#, Yanbo Yuan#, Sha Liu, Cheng Wang, Fude Yang, Zheng Lu, Chuanyue Wang, Hong Deng, Jinping Zhao, Yan Shen, Chenyu Zhang*, Xin Yu*, Qi Xu*. Detection of circulating miRNA levels in schizophrenia. Am J Psychiatry. 2015. 172(11):1141-7. (IF=13.50)

9. Yongyong Shi*#, Zhiqiang Li#, Qi Xu#,Ti Wang, Tao Li, Jiawei Shen, Fengyu Zhang, Jianhua Chen, Guoquan Zhou, Weidong Ji, Baojie Li, Yifeng Xu, Dengtang Liu, Peng Wang, Ping Yang, Benxiu Liu, Wensheng Sun, Chunling Wan, Shengying Qin, Guang He, Stacy Steinberg, Sven Cichon, Thomas Werge, Engilbert Sigurdsson, Sarah Tosato, Aarno Palotie, Markus M N?then, Marcella Rietschel, Roel A Ophoff, David A Collier, Dan Rujescu, David St Clair, Hreinn Stefansson, Kari Stefansson, Jue Ji, Qingzhong Wang, Wenjin Li, Linqing Zheng, Hairong Zhang, Guoyin Feng,Lin He*. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat Genet. 2011. 43(12):1224-7. (IF=35.53, C100)

10. Weirui Guo#, Yanbo Chen#, Xiaohong Zhou#, Amar Kar, Payal Ray, Xiaoping Chen, Elizabeth J Rao, Mengxue Yang, Haihong Ye, Li Zhu, Jianghong Liu, Meng Xu, Yanlian Yang, Chen Wang, David Zhang, Eileen H Bigio, Marsel Mesulam, Yan Shen, Qi Xu*, Kazuo Fushimi, Jane Y Wu*. An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. Nat Struct Mol Biol. 2011. 18(7):822-30. (IF=12.71, C100)