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皮肤病医院

  • 姓 名:

    陆前进

  • 单 位:

    天美麻花星空视频皮肤病医院(天美麻花星空视频皮肤病研究所)

  • 教职岗位:

    教授

  • 聘任时间:

    2021-03-31

  • 一级学科:

    临床医学

  • 二级学科:

    皮肤病与性病学

  • 联系方式:

    qianlu5860@pumcderm.cams.cn

  • 导师风采链接:

个人介绍

陆前进,1962年出生,籍贯湖南衡阳,长聘教授,博士生导师,天美麻花星空视频皮肤病医院(研究所)执行院(所)长,中华医学会皮肤性病学分会主任委员,亚洲皮肤病学会理事,从事皮肤科临床、教学及科研三十余年,在国际上首次命名一种新型红斑狼疮,建立了红斑狼疮表观遗传发病机制理论,牵头制定国际皮肤型红斑狼疮诊疗指南。以第一作者或通信作者在Lancet,JAMA,Blood,J Clin Invest等国际著名医学杂志发表SCI论文200余篇,作为第一完成人获国家科技进步二等奖等奖项。


主要研究方向

擅长自身免疫性皮肤病表观遗传机制、转化与临床研究,建立了系统性红斑狼疮表观遗传发病机制新理论,创建红斑狼疮 DNA甲基化诊断新技术,研发红斑狼疮等皮肤病人工智能辅助诊断新工具,突破现有诊断瓶颈。


代表性成果

天美麻花星空视频

1. Gao X#, Song Y#, Wu J, Lu S, Min X, Liu L, Hu L, Zheng M, Du P, Yu Y, Long H, Wu H, Jia S, Yu D, Lu Q*, Zhao M*. Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus. J Clin Invest. 2022 May 2;132(9):e152345. (IF=19.456)

2. Yang M#, Long D, Hu L, Zhao Z, Li Q, Guo Y, He Z, Zhao M, Lu L, Li F, Long H, Wu H*, Lu Q*. AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation. Signal Transduct Target Ther. 2021 Sep 14;6(1):341. (IF=18.187)

3. Wang Z#, Zhao M#, Yin J, Liu L, Hu L, Huang Y, Liu A, Ouyang J, Min X, Rao S, Zhou W, Wu H, Yoshimura A, Lu Q*. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases. J Clin Invest. 2020 Jul 1;130(7):3717-3733. (IF=14.808)

4. Ding S#, Zhang Q, Luo S, Gao L, Huang J, Lu J, Chen J, Zeng Q, Guo A, Zeng J*, Lu Q*. BCL-6 suppresses miR-142-3p/5p expression in SLE CD4+ T cells by modulating histone methylation and acetylation of the miR-142 promoter. Cell Mol Immunol.2020 May;17(5):474-482. (IF=11.530)

5.Liu Y#, Sawalha AH*, Lu Q*. COVID-19 and autoimmune diseases. Curr Opin Rheumatol. 2021 Mar 1;33(2):155-162. (IF=5.006, ESI)

6. Liu X#, Zhang W#, Zhao M#, Fu L, Liu L, Wu J, Luo S, Wang L, Wang Z, Lin L, Liu Y, Wang S, Yang Y, Luo L, Jiang J, Wang X, Tan Y, Li T, Zhu B, Zhao Y, Gao X, Wan Z, Huang C, Fang M, Li Q, Peng H, Liao X, Chen J, Li F, Ling G, Zhao H, Luo H, Xiang Z, Liao J, Liu Y, Yin H, Long H, Wu H, Yang H, Wang J, Lu Q*. T cell receptor β repertoires as novel diagnostic markers for systemic lupus erythematosus and rheumatoid arthritis. Ann Rheum Dis. 2019 Aug;78(8):1070-1078. (IF=16.102)

7. Wu R#, Zeng J#, Yuan J, Deng X, Huang Y, Chen L, Zhang P, Feng H, Liu Z, Wang Z, Gao X, Wu H, Wang H, Su Y, Zhao M, Lu Q*. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation. J Clin Invest. 2018 Jun 1;128(6):2551-2568. (IF=12.282, C100)

8. Wu H#, Deng Y, Feng Y, Long D, Ma K, Wang X, Zhao M, Lu L*, Lu Q*. Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity. Cell Mol Immunol. 2018 Jul;15(7):676-684.(IF=8.213)

9. Zhao M#, Zhou Y, Zhu B, Wan M, Jiang T, Tan Q, Liu Y, Jiang J, Luo S, Tan Y, Wu H, Renauer P, Del Mar Ayala Gutiérrez M, Castillo Palma MJ, Ortega Castro R, Fernández-Roldán C, Raya E, Faria R, Carvalho C, Alarcón-Riquelme ME, Xiang Z, Chen J, Li F, Ling G, Zhao H, Liao X, Lin Y, Sawalha AH*, Lu Q*. IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus. Ann Rheum Dis. 2016 Nov;75(11):1998-2006.(IF=12.811, C100)

10. Zhao S#, Wang Y, Liang Y, Zhao M, Long H, Ding S, Yin H, Lu Q*. MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum. 2011 May;63(5):1376-86. (IF=10.995, ESI)