车永胜，1966年生，籍贯齐齐哈尔，医药生物技术所研究员，博士生导师。1989年获南开大学化学学士学位，1995年获美国Clarkson大学有机化学硕士学位，2000年获美国Iowa大学微生物药物化学博士学位。2000年开始在OSI (Astellas)与Givaudan分别从事天然药物与功能产物研发。2005年入职中科院微生物所研究员、博士生导师，2010年进入军事医学科学院毒物药物所，2018年进入医药生物技术研究所。

主要从事微生物药源分子的高效发现策略、产生途径与机制，以及合成生物学制备技术研究。

天美麻花星空视频

1. Li X,# Cui J,# Zheng W,# Zhang J,# Li R, Ma X, Lin M, Guo H, Li C, Yu X, Du P, Zhao L, He S, Lan P, Jiang J,* Che Y,* Wang L.* Bicyclol alleviates atherosclerosis by manipulating gut microbiota. Small 2022, 18(9): e2105021. (IF = 15.153).

2. Yan H,# Sun J,# Wang K,# Wang H, Wu S, Bao L, He W, Wang D, Zhu A, Zhang T, Gao R, Dong B, Li J, Yang L, Zhong M, Lv Q, Qin F,  Zhuang Z, Huang X, Yang X, Li Y,* Che Y,* Jiang J.* Repurposing CFDA-approved drug carrimycin as an antiviral agent against human coronavirsues, including the currently pandemic SARS-CoV-2. Acta Pharm Sin B 2021, 11(9): 2850-2858. (IF = 14.903)

3. Zhu S, Ren F, Guo Z, Liu J, Liu X, Liu G, Che Y.* Rogersonins A and B, imidazolone N-oxide-incorporating indole alkaloids from a verG disruption mutant of Clonostachys rogersoniana. J Nat Prod 2019, 82(2): 462–468. (IF = 4.257)

4. Liu J, Zhai Y, Zhu S, Liu G,* Che Y.* Heterologous biosynthesis of fungal sesquiterpene trichodermol in Saccharomyces cerevisiae. Front Microbiol 2018, 9: 1773. (IF = 4.259).

5. Yan S,# Liu L,# Ren F, Gao Q, Xu S, Hou B, Jiang X,* Che Y.* Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1. Cell Death Dis 2017, 8: e2988. (IF = 5.638)

6. Wang L,# Feng Y,# Tian J, Xiang M, Sun J, Ding J, Yin W, Stadler M, Che Y,* Liu X.* Farming of a defensive fungal mutualist by an attelabid weevil. The ISME J 2015, 9: 1793–1801. (IF = 9.328)

7. Xiao Z,# Li L,# Li Y,# Zhou W,* Liu F, Cheng J, Liu F, Zheng P, Zhang Y,* Che Y.* Rasfonin, a novel 2-pyrone derivative, induces ras mutated Panc-1 pancreatic tumor cell death in nude mice. Cell Death Dis 2014, 5: e1241. (IF = 5.014)

8. Yuan Y,# Feng Y,# Ren F, Niu S, Liu X, Che Y.* A botryane metabolite with a new hexacyclic skeleton from an entomogenous fungus Hypocrea sp. Org Lett 2013, 15(23): 6050–6053. (IF = 6.324)

9. Li E, Zhang F, Niu S, Liu X, Liu G, Che Y.* A spiro[chroman-3,7’-isochromene]-4,6’(8’H)-dione from the Cordyceps-colonizing fungus Fimetariella sp. Org Lett 2012, 14(13): 3320–3323. (IF = 6.142)

10. Li J, Li L, Si Y, Jiang X, Guo L, Che Y.* Virgatolides A–C, benzannulated spiroketals from the plant endophytic fungus Pestalotiopsis virgatula. Org Lett 2011, 13 (10): 2670–2673. (IF = 5.862)